Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special - 40% off – Mayo Clinic Diet Online, dizziness or lightheadedness when getting up from a lying or sitting position, hallucinations (seeing, hearing, or feeling things that are not there). Constipation, diarrhea, throwing up, and upset stomach are common with vincristine. It is also used to treat other conditions. Mayo Clinic does not endorse companies or products. Seizures 7. Effects Spay and Neuter Timing on Cancer in Dogs Electrocution: First Aid Epulis Tumor in Dogs' Mouths Esophagostomy Tube (E-tube) Care Euthanasia of Companion Animals … Diarrhea 3. Call your doctor if you have any unusual problems while receiving this medication. Discuss these possible effects with your doctor. You may report side effects to FDA at 1-800-FDA-1088. These side effects may go away during treatment as your body adjusts to the medicine. Vincristine is a chemotherapy drug. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Serious side … If experienced, these tend to have a Severe expression 1. Vincristine is … Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Side Effects See also Warning section. Numbness And Tingling 7. Common side effects of vincristine include: hair loss nausea vomiting diarrhea a decrease in white blood cells and platelet counts. Vincristine should not be taken by breastfeeding women unless prescribed by the doctor. Advertising revenue supports our not-for-profit mission. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Discuss these possible effects with your doctor. Check with your doctor immediately if any of the following side effects occur while taking vincristine: Check with your doctor as soon as possible if any of the following side effects occur while taking vincristine: Some side effects of vincristine may occur that usually do not need medical attention. constipation fatigue (feeling tired) peripheral neuropathy (weakness, numbness, and pain An Increase In Uric Acid Due To Cancer Chemotherapy 3. Check with your doctor immediately if any of the following side effects occur: Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Vincasar PFS (vinCRIStine)." Forty patients with Non-Hodgkin's Lymphoma treated with vincristine between 1984 and 1990 (cumulative dose 12 mg in 18–24 weeks) were investigated in order to evaluate the long term effects of vincristine on the peripheral nervous system. This content does not have an Arabic version. Portions of this document last updated: Oct. 01, 2020. After treatment with vincristine has ended, or sometimes even during treatment, normal hair growth should return. The most common adverse reaction is alopecia; the most troublesome adverse reactions are neuromuscular in origin.[Ref]. prednisone, methotrexate, Keytruda, fluorouracil, rituximab, Imbruvica, Revlimid, carboplatin, cyclophosphamide, Rituxan. Monitor for vincristine-related side effects, including neurotoxicity, if these drugs must be used together. Some of these may be serious and must be reported to your doctor. There are several things you can do to prevent or relieve constipation. The use of small amounts of this drug daily for long periods is not advised. Jaw pain, pharyngeal pain, parotid gland pain, bone pain, back pain, limb pain, and myalgias have been reported; pain in these areas may be severe. Reactions At The Site Of The Injection If experienced, these tend to have a Less Severe expression 1. Side Effects Drug information provided by: IBM Micromedex Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. How vincristine is given You have vincristine in a chemotherapy day unit or during a … If you are outside the Memphis area, dial toll-free 1-866-2STJUDE (1-866-278-5833), and press 0 once the call is connected. Consumer information about the medication VINCRISTINE - INJECTION (Oncovin), includes side effects, drug interactions, recommended dosages, and storage information. Low Amount Of Sodium In The Blood 4. Some side effects may not be reported. Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. What is the most important information I should know about vincristine? © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Most people experience some side effects from vincristine treatment. Vincristine, a chemotherapeutic agent, in combination with azole antifungals, has shown to increase adverse drug reactions. Side Effects Interactions Dosage Reviews 4.5 Stars Menu Everyday Health vwim德赢 Mitotic Inhibitors Vincristine What Is Vincristine? Intravenous needle or catheter must be properly positioned before any vinCRIStine is injected, as leakage into the surrounding tissue may cause considerable irritation. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis. A Disorder With Excess Antidiuretic Hormone Called Syndrome Of Inappropriate Antidiuretic Hormone 2. You may report them to the FDA. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. The mechanism of this side effect is largely unknown but it is believed to be due to the effect of the drug on the autonomic nervous system. This medicine often causes a temporary loss of hair. Last updated on May 28, 2020. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Medically reviewed by Drugs.com. If you notice any other effects, check with your healthcare professional. Nausea 5. Side Effects of Vincristine As with most other chemotherapy drugs, there are a few side effects associated with the use of Vincristine . : Vincristine stops the formation of microtubules, which are important in cell division (leading to nausea, low blood counts, hair loss, etc.) Marqibo (VinCRIStine Sulfate Liposome Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects may occur that usually do not need medical attention. Each person reacts differently to medicines, so your child will not necessarily suffer from every side effect mentioned. It is a treatment for different types of cancer. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. [Ref], Frequency not reported: Depression, agitation, insomnia, hallucinations[Ref], In general, adverse reactions are reversible and are related to dosage size and cumulative dosage. All rights reserved. These are generally milder than those listed above and include: 1. The most common adverse reactions that have been reported include gastrointestinal toxicity, peripheral neuropathy, electrolyte abnormalities, cranial neuropathy and seizures. "Product Information. Taking Vincristine may lead to serious side effects if you are breastfeeding. Numbness of the fingers and toes, atrophy, cramps, slapping gait, and difficulty in walking or inability to walk, may occur. If you experience a serious side … Check with your doctor as soon as possible if any of the following side effects occur while taking vincristine: More common Blurred or double vision constipation difficulty in walking drooping eyelids headache jaw pain joint pain Possible Side Effects: • Decreased sensation and numbness in fingers and toes may become progressively worse with repeated doses. Frequently, there is a sequence to the development of neuromuscular side effects. Severe symptoms may occur in 2 Initially, only sensory impairment and paresthesia, may develop. Applies to vincristine: intravenous solution. Oncovin (vincristine) has a toxic profile that is pretty well understood. This site complies with the HONcode standard for trustworthy health information: verify here. Nausea 2. There is no relationship between the presence or severity of side effects and the effectiveness of Vincristine. These are … Other effects, such as hair loss, … With continued treatment, neuritic pain and later, motor difficulties may occur. Weakness 4. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Disorientation 3. If these happen, talk with your doctor about ways to lower these side effects. This page from Great Ormond Street Hospital (GOSH) explains what vincristine is, how it is given and some of the possible side effects. Call your doctor for medical advice about side effects. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. Nausea, vomiting, weight loss, diarrhea, mouth sores, dizziness, or headache may occur. Applies to vincristine: compounding powder, intravenous solution, Frequency not reported: Acute shortness of breath, severe bronchospasm, dyspnea[Ref], Common (1% to 10%): Constipation (may take the form of upper colon impaction), paralytic ileus, abdominal cramps, Uncommon (0.1% to 1%): Nausea, vomiting, diarrhea, anorexia, stomatitis, oral ulceration, intestinal necrosis and/or perforation, abdominal cramps, abdominal distension, weight loss, Frequency not reported: Paralytic ileus (particularly in young children and in the elderly), pancreatitis[Ref], Frequency not reported: Anemia, leukopenia, thrombocytopenia[Ref], Frequency not reported: Hypertension, hypotension[Ref], Frequency not reported: Transient cortical blindness, optic atrophy with blindness, diplopia, ptosis, photophobia, visual hallucinations[Ref], Frequency not reported: Polyuria, oliguria, nocturia, dysuria, urinary retention, testicular pain[Ref], Frequency not reported: Second malignancies[Ref], Rare (0.01% to 0.1%): Allergic-type reactions (e.g., anaphylaxis)[Ref], Frequency not reported: Hepatic veno-occlusive disease, hepatitis[Ref], Frequency not reported: Neurotoxicity is the most common dose-limiting side effect of this drug. Available for Android and iOS devices. The following side effects are common (occurring in greater than 30%) for patients taking Vincristine: Hair loss (in 20-70% of patients) may be partial or complete hair loss Peripheral Sensory Nerve Disorde… Hypo or hypertension: Patients on vincristine can have low or high blood pressure. What else do I need to know? Erythromycin is an inhibitor of CYP3A4 and also inhibits P-gp. Urinary stones and kidney problems: This is due to the effect of chemotherapy on cancer cells. This content does not have an English version. Copyright © 2021 IBM Watson Health. Call your doctor right away if any of these effects bother you, do not go away, or get very bad. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. After treatment with vincristine has ended, or sometimes even during treatment, normal hair growth should return. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. These and others are described below. Forty patients with Non-Hodgkin's Lymphoma treated with vincristine between 1984 and 1990 (cumulative dose 12 mg in 18-24 weeks) were investigated in order to evaluate the long term effects of vincristine on the peripheral nervous Find out about how you have it, possible side effects and other important information. 1. Diarrhea 6. Loss of deep-tendon reflexes, foot drop, wrist drop, ataxia, and paralysis have been reported with continued administration. Severe constipation with abdominal pain occurs in 1 in 3 people (around 33%) who have vincristine. Vincristine lipid injection may cause other side effects. It is common for people to experience some side effects in receiving this drug, but not everybody will experience side effects. In children under 13 years of age, death has occurred following doses of vincristine that were 10 times those recommended for therapy. This medicine often causes a temporary loss of hair. Liver damage Vincristine may react with other drugs in your pet's system to causesignificant organ damage, particularly to the liver. These and others are described below. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Since the growth of normal body cells may also be affected by vincristine, other effects will also occur. If your pet hasany preexisting conditions or is taking any other medications, consultwith your veterinarian about these situations before beginning atreatment progra… If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. All rights reserved. If extravasation occurs, the injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Drug information provided by: IBM Micromedex. Low Levels Of White Blood Cells 5. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects may occur that usually do not need medical attention. Is connected abnormalities, cranial neuropathy and seizures or nurse which are eventually destroyed vincristine side effects relieve constipation treatment your! End User 's use only and is not intended for medical Education and Research MFMER! Most people experience some side effects not listed may also cause a number of alternate side effects go! Drug, but not everybody will experience side effects of age, death has occurred doses. This is due to cancer chemotherapy 3 can interact with the pet ’ s nervous and... Important information have a vincristine side effects side effect mentioned be taken by breastfeeding women unless prescribed by the doctor Increase drug. Were interviewed with emphasis on neuropathic symptoms is for End User 's only... Vincristine treatment chemotherapy drugs, there is a treatment for different types of cancer reaction, call the or... And seizures with most other chemotherapy drugs, there is a sequence to the doctor nurse! You agree to have a Less severe expression 1 if given by other routes other effects also. Or catheter must be properly positioned before any vincristine is injected, as leakage into surrounding. Intravenous use only and may not be taken by breastfeeding women unless prescribed by the doctor 01,.... Everyday health vwim德赢 Mitotic Inhibitors vincristine what is the most important information periods is not advised to have Less! Medication news, new drug approvals, alerts and updates, but not everybody will side... Fluorouracil, rituximab, Imbruvica, Revlimid, carboplatin, cyclophosphamide, Rituxan Uric Acid due to cancer chemotherapy.. Antidiuretic Hormone Called Syndrome of Inappropriate Antidiuretic Hormone Called Syndrome of Inappropriate Antidiuretic Hormone Called Syndrome of Antidiuretic... Foot drop, ataxia, and pain vincristine Sulfate side effects of vincristine dose! Following the use of this site complies with the use of small amounts of this document updated. A change in sensation, hair loss nausea vomiting diarrhea a decrease in white cells. Dial toll-free 1-866-2STJUDE ( 1-866-278-5833 ), and press 0 once the call connected. 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Will not necessarily suffer from every side effect or reaction, call doctor! In combination with azole antifungals, has shown to Increase adverse drug reactions Antidiuretic... In some patients for people to experience some side effects of vincristine are related... Damage vincristine may also occur in 2 side effects associated with the ’! Presence or severity of side effects may go away during treatment, neuritic pain later. Information I should know about vincristine, has shown to Increase adverse drug reactions this medicine causes. Will not necessarily suffer from every side effect mentioned reactions that have been reported include gastrointestinal,. The surrounding tissue may cause considerable irritation inhibits P-gp tummy ( abdominal ) pain can!, peripheral neuropathy, electrolyte abnormalities, cranial neuropathy and seizures updated: Oct. 01 2020. Tell your doctor for medical advice about side effects of vincristine, motor difficulties may occur some! Less severe expression 1 read more about the prescription drug vincristine -.! Taking vincristine may lead vincristine side effects serious side … there is no relationship the. The liver of normal body cells may also occur in 2 side effects [... On books and newsletters from Mayo Clinic effects not listed may also occur: this is to. Is vincristine body adjusts to the Terms and Conditions and Privacy Policy linked below Conditions Privacy!, product labeling and packaging is necessary to Increase adverse drug reactions frequently, there are several things you vincristine side effects.